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KMID : 0388220120190030147
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Journal of the Korean Rheumatism Association
2012 Volume.19 No. 3 p.147 ~ p.151
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A Case of Intestinal Behcet’s Disease Complicated Enterocutanous Fistula with a Good Response to Adalimumab
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Oh Il-Hwan
Kim Jin-Ok
Byun Young-Jae
Sung Yoon-Kyoung
Choi Chan-Bum
Kim Tae-Hwan
Jun Jae-Bum
Uhm Wan-Sik
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Abstract
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Behcet’s disease (BD) is a multisystemic disorder, which is characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesion. Although intestinal involvement is an uncommon manifestation of the BD, it leads to a poor prognosis, as a result of a high complication, such as intestinal perforation, fistula formation, and massive hemorrhage. Intestinal BD has the tendency for the resistance to conventional medical treatment, and it often requires a surgical intervention because of severe complication. Although the causes of intestinal BD are unknown, some studies show that tumor necrosis factor Alpha (TNF-?) plays a key role in the pathogenesis of BD. Therefore, anti-TNF-? monoclonal antibody, such as adalimumab, is one of the useful treatment for refractory and relapsed intestinal BD. We describe a patient who had intestinal BD complicated enterocutanous fistula with a good response to adalimumab.
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KEYWORD
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Behcet’s disease, Intestine, TNF-?, Adalimumab
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